Zeolite Research & Scientific Papers on Clinoptilolite

The safety and toxicity is of primary concern to all consumers. Here is a small selection of some of the scientific papers and abstracts sharing the knowledge that Clinoptilolite is safe to consume and has no toxic side effects. After years of vigorous research there are now over 200 scientific papers that have been published. Clink on links to the specific scientific paper abstracts. The numerous research papers over many years demonstrate that Clinoptilolite is safe and non-toxic and we hope that medical practitioners and their patients review some of these papers.

1	Enterex: Anti-diarrheic drug based on purified natural clinoptilolite
	Clinoptilolite has been approved for use as an anti-diarrheic drug. Enterex: Anti-diarrheic drug based on purified natural clinoptilolite
	G. Rodríguez-Fuentes, M.A. Barrios, A. Iraizoz, I. Perdomo and B. Cedré
2	Antiviral properties of clinoptilolite
	Antiviral properties of clinoptilolite of this study suggest that there is a therapeutical case for clinoptilolite against the herpes virus.
	Magdalena Grce, and Kreimir Pavelic
3	Anticancer and antioxidative effects of micronized zeolite clinoptilolite.
	The anticancer and antioxidative effects of micronized zeolite clinoptilolite showed a reduction in the cancer count.
	Zarkovic N, Zarkovic K, Kralj M, Borovic S, Sabolovic S, Blazi MP
4	Natural zeolite clinoptilolite: new adjuvant in anticancer therapy.
	Natural zeolite clinoptilolite: new adjuvant in anticancer therapy.
	Pavelic K, Hadzija M, Bedrica L, Pavelic J, Dikic I, Katic M, Kralj M,
5	The effect of natural clinoptilolite on the serotonergic receptors in the brain of mice with mammary carcinoma.
	The effect of natural clinoptilolite on the serotonergic receptors in the brain of mice showed that there was a beneficial effect on those mice with mammary carcinoma.
	Mück-Seler D, Pivac N.
6	Dietary supplementation with the tribomechanically activated zeolite clinoptilolite in immunodeficiency: effects on the immune system.
	Dietary supplementation with an activated zeolite clinoptilolite in immunodeficiency: effects on the immune system which showed no adverse reactions to the treatment.
	Ivkovic S, Deutsch U, Silberbach A, Walraph E, Mannel M.
7	A clinoptilolite effect on cell media and the consequent effects on tumor cells in vitro.
	Clinoptilolite effects the cellular micro-environment of cell media and consequently, has an effect on tumour cells in vitro.
	Katic M, Bosnjak B, Gall-Troselj K, Dikic I, Pavelic K.
8	Natural zeolite clinoptilolite: new adjuvant in anticancer therapy.
	Mice and dogs suffering from cancer tumours had improved health and longer life span after clinoptilolite powder was used to treat their tumours. The treatment showed no negative effects.
	Pavelic K, Hadzija M, Bedrica L, Pavelic J, Dikic I, Katic M, Kralj M,
9	Pulmonary alveolar macrophage cytotoxicity investigation of irregular shape mineral dusts
	Investigation of cytotoxicity of six mineral dusts from 12 deposits. Results showed that clinoptilolite and one other, being rounded in shape, had no AM cytotoxicity.
	Dong F, Deng J, Pu X, John H.
10	Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite.
	This interesting report investigates the possible dangers of zeolite. Of the zeolites is said that they were not significantly toxic in oral acute or short term oral or parental studies in animals. Reference was made to inhalation toxicity. But these concerns relate only to large particle size, long, wide fibres which are not found in clinoptilolite.
	Elmore AR; Cosmetic Ingredient Review Expert Panel.
11	Study on carcinogenicity of clinoptilolite type zeolite in Wistar rats.
	Toxic Effect. Various materials were introduced into the lungs of rats and the lung tissue examined after 90, 180 and 360 days. Clinoptilolite was found to be inert while all the others showed cytotoxic effects to some degree.
	Abstract The effects of samples of crystalline quartz, diatomaceous earth, mordenite and clinoptilolite were investigated in vitro (as concerns erythrocyte haemolysis and lactate dehydrogenase (LDH) release from peritoneal macrophages) and in vivo (on LDH, protein and phospholipids in rat bronchoalveolar lavage (BAL), and phospholipids in rat lung tissue). The respirable mineral samples were instilled intratracheally. Determinations in the BAL were carried out after 15, 60 and 180 days, and in the lung tissue after 90, 180 and 360 days. Quartz DQ and quartz FQ induced acute, subacute and chronic inflammation and progressive fibrosis. However, due to the Al2O3 contamination on the surface of the particles quartz FQ caused a delayed response in vivo. Diatomaceous earth produced acute/subacute inflammation that gradually became more moderate after 60 days. Clinoptilolite was inert, whereas the other zeolite sample, mordenite, was cytotoxic in vivo. The reason for this was presumably the needle and rod-shaped particles in the mordenite samples. The investigation revealed that different in vitro and in vivo methods can provide valuable data concerning the pulmonary toxicity of minerals.
12	Distribution of dichlorvos in the rat and the effect of clinoptilolite on poisoning
	This study showed that clinoptilolite had no carcinogenic incidence of tumours in any tissues or organs and no carcinogenic activity in rats.
	Tátrai E, Ungváry G.
13	Preventive effect of zeolite in VX poisoning in rats
	Rats intoxicated with dichlorvos showed that clinoptilolite gave a marked protective effect on most tissues studied.
	Nistiar F, Hrusovský J, Mojzis J, Mizik P.
14	Effects of short-term supplementation of clinoptilolite in colostrum and milk on the concentration of some serum minerals in neonatal dairy calves.
	These rats were intoxicated by VX substance and those which had been given clinoptilolite showed significantly lowered ChE than the control group.
	Mojzis J, Nistiar F, Kovác G, Mojzisová G.
15	The role of natural and synthetic zeolites as feed additives on the prevention and/or the treatment of certain farm animal diseases: A review
	There were no adverse effects of the short-term supplementation of clinoptilolite in colostrum and milk on the concentration of some serum minerals in neonatal dairy calves.
	Mohri M, Seifi HA, Maleki M.
	Abstract The present review comments on the role of the use of zeolites as feed additives on the prevention and/or the treatment of certain farm animal diseases. Both natural and synthetic zeolites have been used in animal nutrition mainly to improve performance traits and, based on their fundamental physicochemical properties, they were also tested and found to be efficacious in the prevention of ammonia and heavy metal toxicities, poisonings as well as radioactive elements uptake and metabolic skeletal defects. During the last decade, their utilization as mycotoxin-binding adsorbents has been a topic of considerable interest and many published research data indicate their potential efficacy against different types of mycotoxins either as a primary material or after specific modifications related to their surface properties. Ingested zeolites are involved in many biochemical processes through ion exchange, adsorption and catalysis. Recent findings support their role in the prevention of certain metabolic diseases in dairy cows, as well as their shifting effect on nitrogen excretion from urine to faeces in monogastric animals, which results in lower aerial ammonia concentration in the confinement facilities. Moreover, new evidence provide insights into potential mechanisms involved in zeolites supporting effect on animals suffered from gastrointestinal disturbances, including intestinal parasite infections. All the proposed mechanisms of zeolites’ effects are summarized in the present review and possible focus topics for further research in selected areas are suggested.
16	Effect of feeding clinoptilolite (zeolite) on the performance of three strains of laying hens.
	In this paper there appears to be no safety or toxicity issues. This is a review of the role of natural and synthetic zeolites as feed additives in the prevention and/or the treatment of certain farm animal diseases. It comments that zeolites perform many beneficial mechanisms and new research suggests that zeolites have the potential to deliver positive effects in cases of gastro-intestinal occurrences and intestinal parasite infections.
	D. Papaioannou, P.D. Katsoulos, N. Panousis and H. Karatzias
17	Protection by clinoptilolite or zeolite NaA against cadmium-induced anemia in growing swine.
	This South African study shows the effect of feeding clinoptilolite (zeolite) on the performance of three strains of laying hens. Although there were differences between the
	Olver MD.
18	In vivo reduction of radiocesium with modified clinoptilolite in sheep
	Pigs feed clinoptilolite NaA were protected against cadmium-induced anemia and their liver minerals were unaffected.
	Pond WG, Yen JT.
19	Effects of long-term feeding dairy cows on a diet supplemented with clinoptilolite on certain serum trace elements.
	Clinoptilolite given to sheep contaminated with radiocaesium showed marked reduction in the amount of contamination.
	Jandl J, Novosad J.
20	Effects of long-term feeding of a diet supplemented with clinoptilolite to dairy cows on the incidence of ketosis, milk yield and liver function.
	A long-term study of feeding a diet supplemented with clinoptilolite to dairy cows showed no adverse effects from week 4 until the end of lactation and the tests conclusion.
	Katsoulos PD, Roubies N, Panousis N, Karatzias H.
21	Effect of clinoptilolite on performance of Japanese quail (Coturnix coturnix japonica) during experimental aflatoxicosis.
	Effects of long-term feeding of a diet supplemented with clinoptilolite to dairy cows on the incidence of ketosis, milk yield and liver function.
	Katsoulos PD, Panousis N, Roubies N, Christaki E, Arsenos G
22	Physiological and toxicological responses in rats fed aflatoxin-contaminated diet with or without sorbent materials
	This study showed that forty Japanese quail chicks given clinoptilolite in their food reduced the detrimental effects of aflatoxicosis. At the end of the study there were no mortalities in any of the study groups.
	Parlat SS, Yildiz AO, Oguz H.
23	Effects of zeolites on cultures of marine micro-algae: A brief review.
	In a trial of rats fed a contaminated diet containing aflatoxin and sorbent materials (natural zeolites) it was determined that the sorbents by themselves had no toxic effects.
	M. A. Abdel-Wahhab, , a, S. A. Nadab and F. A. Khalilc
24	The effect of zeolite on the toxicity of lead to fungi.
	Effects of zeolites on cultures of marine micro-algae: The study showed that the zeolite stimulated the growth of phyto-planktons, the basis of all marine food webs, and was non-
	Fachini A, Vasconcelos MT.
25	In vitro evaluation of the use of zeolites as biomaterials: effects on simulated body fluid and two types of cells.
	The effect of clinoptilolite zeolite on the removal of lead toxicity from fungi without being toxic to the fungi itself.
	Harris JA, Birch P.
26	De-aluminated zeolite Y as a tool to study endocytosis, a delivery system revealing differences between human peripheral dendritic cells.
	When two zeolites were placed in simulated body fluids (‘SBF’) for a period of 14 days no biological effects were observed except a small transfer of potassium.
	Ceyhan T, Tatlier M, Akçakaya H.
27	Comparative efficacy of granular and bagged formulations of the hemostatic agent QuikClot.
	A study in Sweden using de-aluminated zeolite as a method to study endocytosis inside viable human peripheral dendritic cells provided an efficient carrier of bi-molecules into endosomal pathways of viable cells without affecting the cells themselves.
	Andersson LI, Eriksson H.
30	Comparative efficacy of granular and bagged formulations of the hemostatic agent QuikClot.
	QuikClot is a wound dressing approved and deployed by the United States Military to stop bleeding from severe combat wounds.
	Arnaud F, Tomori T, Saito R, McKeague A, Prusaczyk WK, McCarron RM.
28	A case series describing thermal injury resulting from zeolite use for hemorrhage control in combat operations.
	A case series describing thermal injury resulting from zeolite use for haemorrhage control in combat operations.
	McManus J, Hurtado T, Pusateri A, Knoop KJ.
29	Pharmacokinetic study of zeolite A, sodium aluminosilicate, magnesium silicate, and aluminum hydroxide in dogs.
	Pharmacokinetic study of zeolite A, sodium aluminosilicate, magnesium silicate, and aluminium hydroxide in dogs.
	Cefali EA, Nolan JC, McConnell WR, Walters DL.

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Zeolite Research & Scientific Papers on Clinoptilolite

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